I have, and didn't have success with the two apps I was trying to run. That said they weren't on the supported app list.
There are a few games from GOG that I play, that are wrapped in WINE, and they run just fine.
If you really need to run Windows apps, and they aren't compatible, look up veertu desktop. you can install full blown windows. VirtualBox is likely as good, but this seems to be far more tailored to OS X.