Seem to remember a similar issue with ClarisWorks Spreadsheets on my LC475. I turned off the "Auto Calc" menu item and when all my data was up to date clicked on "Calculate Now" then took a bathroom break....Trying to change any aspect of the chart spiked one of the processors at 100%, and caused the whole application to become non-responsive for at least 30 seconds....
Switching over to Excel for now.
Does Numbers retain that useful feature?