ESPI at work: The power of Keynote (http://edenspiekermann.com/en/blog/espi-at-work-the-power-of-keynote)

Keynote is an incredibly powerful design tool. Less then one year later, I now rarely (if ever) use InDesign to layout presentations, and I have started using Keynote almost exclusively for any web layouts I do. And not just UX wireframes, but full UI designs. On a recent project, I also used it for poster mock ups, banner designs and a bunch of other formats....the same layout used for web can also be printed at a lovely 300dpi. This is particularly useful for iPhone/iPad design, as it means a single source version of artwork for Retina and non-Retina displays.

(more at: EdenSpiekermann (http://edenspiekermann.com/en/blog/espi-at-work-the-power-of-keynote) via Lifehacker (http://lifehacker.com/5897210/use-keynote-to-design-documents-web-sites-and-other-atypical-items))

Now, if Apple would just get off their keister and release an update sometime this decade...